UNDERSTANDING MECHANISMS OF RISK AND RESILIENCE THROUGHOUT BRAIN DEVELOPMENT
THE CHALLENGES THAT DRIVE OUR WORK
To understand why some youths who grow up with developmental stress become suicidal, while others do not (resilient).
To timely identify those at risk for serious psychopathology and divert the developmental trajectory from risk to resilience.
THE QUESTIONS WE ASK
What are the mechanisms that drive variability in the development of brain and behavior?
How do environmental (E) exposures (e.g., trauma, neighborhood environment) interact among themselves (E X E), and with biological (e.g., genetic (G)) factors (G X E), to shape developmental trajectories of youth?
Promote resilience and prevent suicide and serious psychiatric outcomes in youths.
Conduct impactful translational science aimed at reducing youth mental health burden.
In the BarziLab, we use multiple methods to understand variability in the development of brain and behavior.
We study how a myriad of environmental exposures (such as trauma and socioeconomic factors) dynamically interact among themselves, and with biological factors (such as genetic and epigenetic) to shape the development of brain and behavior.
We collect and analyze large human datasets.
We do collaborative interdisciplinary science.
We work with basic scientists to inform mechanistic gaps that can only be investigated in animal models.
CONDUCT LONGITUDINAL STUDIES
BarziLab studies at-risk youths throughout development in attempt to elucidate the immune mechanisms associated with risk and resilience to developmental stress.
ANALYSE EXISTING LARGE-SCALE INFORMATIVE DATASETS
BarziLab uses available human datasets that can inform on the factors (features) that drive risk and resilience. We are specifically interested in integrating data from multiple levels of environmental exposures (exposome) with large scale biological data (e.g., genomics, imaging) and other available data sources (such as electronic health records) in order to better understand complex mechanisms of development and to allow prediction of adverse behavioural outcomes such as suicidal behavior.
Identifying subclinical behaviors as markers for serious psychopathology risk
We aim to solve complicated challenges that require a multidisciplinary team of clinicians,
data scientists, geneticists, immunologists, developmental psychologists, basic neuroscientists and computational biologists.
Argabright, S. T., Visoki, E., Moore, T. M., Ryan, D. T., DiDomenico, G. E., Njoroge, W., Taylor, J. H., Guloksuz, S., Gur, R. C., Gur, R. E., Benton, T. D., & Barzilay, R. (2021). Association between discrimination stress and suicidality in preadolescent children. Journal of the American Academy of Child and Adolescent Psychiatry, S0890-8567(21), 01355-1. https://doi.org/10.1016/j.jaac.2021.08.011
Daskalakis, N. P., Schultz, L. M., Visoki, E., Moore, T. M., Argabright, S. T., Harnett, N. H., DiDomenico, G. E., Warrier, V., Almasy, L., & Barzilay, R. (2021). Contributions of PTSD polygenic risk and environmental stress to suicidality in preadolescents. Neurobiology of Stress, 15. https://doi.org/10.1101/2021.05.30.21258082
Alexander-Bloch, A. F., Sood, R., Shinohara, R. T., Moore, T. M., Calkins, M. E., Chertavian, C., Wolf, D. H., Gur, R. C., Satterthwaite, T. D., Gur, R. E., & Barzilay, R. (2021). Connectome-wide functional connectivity abnormalities in youth with obsessive compulsive symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Advance online publication. https://doi.org/10.1016/j.bpsc.2021.07.014
Hertz-Palmor, N., Moore, T. M., Gothelf, D., DiDomenico, G. E., Dekel, I., Greenberg, D. M., Brown, L. A., Matalon, N., Visoki, E., White, L. K., Himes, M. M., Schwartz-Lifshitz, M., Gross, R., Gur, R. C., Gur, R. E., Pessach, I. M., & Barzilay, R. (2021). Association among income loss, financial strain and depressive symptoms during COVID-19: Evidence from two longitudinal studies. Journal of Affective Disorders, 291, 1–8. https://doi.org/10.1016/j.jad.2021.04.054
Shoval, G., Visoki, E., Moore, T. M., DiDomenico, G. E., Argabright, S. T., Huffnagle, N. J., Alexander-Bloch, A. F., Waller, R., Keele, L., Benton, T. D., Gur, R. E., & Barzilay, R. (2021). Evaluation of attention-deficit/hyperactivity disorder medications, externalizing symptoms, and suicidality in children. JAMA Network Open, 4(6), e2111342. https://doi.org/10.1001/jamanetworkopen.2021.11342
Barzilay, R., Moore, T. M., Calkins, M. E., Maliackel, L., Jones, J. D., Boyd, R. C., Warrier, V., Benton, T. D., Oquendo, M. A., Gur, R. C., & Gur, R. E. (2021). Deconstructing the role of the exposome in youth suicidal ideation: Trauma, neighborhood environment, developmental and gender effects. Neurobiology of Stress, 14, 100314. https://doi.org/10.1016/j.ynstr.2021.100314
Barzilay, R., Moore, T. M., Greenberg, D. M., DiDomenico, G. E., Brown, L. A., White, L. K., Gur, R. C., & Gur, R. E. (2020). Resilience, COVID-19-related stress, anxiety and depression during the pandemic in a large population enriched for healthcare providers. Translational Psychiatry, 10(1), 291. https://doi.org/10.1038/s41398-020-00982-4
Barzilay, R., Patrick, A., Calkins, M. E., Moore, T. M., Wolf, D. H., Benton, T. D., Leckman, J. F., Gur, R. C., & Gur, R. E. (2019). Obsessive-compulsive symptomatology in community youth: typical development or a red flag for psychopathology?. Journal of the American Academy of Child and Adolescent Psychiatry, 58(2), 277–286. https://doi.org/10.1016/j.jaac.2018.06.038
Featured in Medscape: “Obsessive-Compulsive Symptoms May Herald Mental Illness in Youth”
Barzilay, R., Calkins, M. E., Moore, T. M., Wolf, D. H., Satterthwaite, T. D., Cobb Scott, J., Jones, J. D., Benton, T. D., Gur, R. C., & Gur, R. E. (2019). Association between traumatic stress load, psychopathology, and cognition in the Philadelphia Neurodevelopmental Cohort. Psychological Medicine, 49(2), 325–334. https://doi.org/10.1017/S0033291718000880